Progressive multifocal leukoencephalopathy: new concepts
نویسندگان
چکیده
منابع مشابه
Progressive multifocal leukoencephalopathy: new concepts Leucoencefalopatia multifocal progressiva: novos conceitos
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by reactivation of JC virus ( JCV). Primary infection occurs in childhood and it is asymptomatic in most patients. Thereafter, the virus remains latent in the kidney, bone marrow and lymphoid organs, but, in a setting of cellular immunosuppression, the virus reactivates, spreads to the central ner...
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There has been recent progress in the area of John-Cunningham virus (JCV) infection and progressive multifocal leukoencephalopathy (PML). New drugs and better reporting identify new risk cohorts and importantly development of new risk assessment strategies. The clinical presentation has not changed, but presentation of rarer forms of JCV infection are now apparent. Brain magnetic resonance imag...
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Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...
متن کاملProgressive Multifocal Leukoencephalopathy.
Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts. Once reactivated, JCV infects oligodendrocytes and a...
متن کاملProgressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John C...
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ژورنال
عنوان ژورنال: Arquivos de Neuro-Psiquiatria
سال: 2013
ISSN: 0004-282X
DOI: 10.1590/0004-282x20130154